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Best over counter medications - January 2026

Last Updated - January 20, 2026

1
Best Choice

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Advil

Advil Liqui-Gels minis Pain Reliever and Fever Reducer, Pain Medicine for Adults with Ibuprofen 200mg for Pain Relief - 200 Liquid Filled Capsules

Advil

$23.94

More Details
Main highlights
- Take these Advil mini Liqui-Gels as directed - the perfect addition to your college dorm room essentials
- Pain reliever and fever reducer for adults designed for fast absorption, with the same strength as regular size Advil Liqui-Gels
- One bottle of 200 Advil Liqui-Gels minis Pain Reliever and Fever Reducer Liquid Filled Capsules, Pain Medicine for Adults with Ibuprofen 200mg for Pain Relief
- Liqui-Gel Minis are easy to swallow - the perfect addition to your college dorm room essentials
- Headache medicine, back pain medicine and joint or minor arthritis pain reliever that are faster and stronger on tough pain than Tylenol Rapid Release Gels
- HSA and FSA eligible product
- Fever medicine and headache pain relief, period pain relief, joint pain medicine and back pain medication for adults and children 12 years and older
$23.94
2

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Advil

Advil Liqui-Gels minis Pain Reliever and Fever Reducer, Pain Medicine for Adults with Ibuprofen 200mg for Pain Relief - 200 Liquid Filled Capsules

Advil

$22.74

$23.94
(5% Off)

More Details
Main highlights
- Take these Advil mini Liqui-Gels as directed - the perfect addition to your college dorm room essentials
- Pain reliever and fever reducer for adults designed for fast absorption, with the same strength as regular size Advil Liqui-Gels
- One bottle of 200 Advil Liqui-Gels minis Pain Reliever and Fever Reducer Liquid Filled Capsules, Pain Medicine for Adults with Ibuprofen 200mg for Pain Relief
- Liqui-Gel Minis are easy to swallow - the perfect addition to your college dorm room essentials
- Headache medicine, back pain medicine and joint or minor arthritis pain reliever that are faster and stronger on tough pain than Tylenol Rapid Release Gels
- HSA and FSA eligible product
- Fever medicine and headache pain relief, period pain relief, joint pain medicine and back pain medication for adults and children 12 years and older
$22.74
$23.94 (5% Off)
3
25% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Tylenol
25% Off

Tylenol Extra Strength Acetaminophen Rapid Release Gels, Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes for Fast Release, Gentle on Stomach, 500 mg Per Gelcap, 100 Count OTC Medicine

Tylenol

$12.47

$16.59
(25% Off)

More Details
Main highlights
- Rapid-release technology: Laser-drilled holes in each gelcap release acetaminophen faster for extra strength pain relief; gelcaps are gentle on the stomach and suitable for adults and children 12 years and older
- Multi-symptom support: Use as a fever reducer and to relieve headache, backache, muscle aches, arthritis pain, toothache, and joint discomfort; also helps with menstrual and premenstrual cramps and pain from the common cold or flu
- Fast-acting relief: Tylenol Extra Strength Rapid Release Gels feature 500 mg acetaminophen per gelcap to temporarily relieve minor aches and pains from headache, backache, arthritis, toothache, menstrual cramps, muscle aches, and fever; 100-count
- Dosage instructions: Adults and children 12 years and older take two gelcaps every six hours while symptoms last; do not exceed six gelcaps in 24 hours; always follow the label directions for safe use of acetaminophen and dosing guidance
- Doctor-recommended brand: Choose Tylenol, the #1 doctor-recommended brand for pain relief and fever reduction based on 2021 IQVIA survey; over-the-counter medication with 500 mg acetaminophen per gelcap that’s gentle on the stomach
$12.47
$16.59 (25% Off)
4
29% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Tylenol
29% Off

Tylenol Extra Strength Acetaminophen Rapid Release Gels, Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes for Fast Release, Gentle on Stomach, 500 mg Per Gelcap, 100 Count OTC Medicine

Tylenol

$11.85

$16.59
(29% Off)

More Details
Main highlights
- Rapid-release technology: Laser-drilled holes in each gelcap release acetaminophen faster for extra strength pain relief; gelcaps are gentle on the stomach and suitable for adults and children 12 years and older
- Multi-symptom support: Use as a fever reducer and to relieve headache, backache, muscle aches, arthritis pain, toothache, and joint discomfort; also helps with menstrual and premenstrual cramps and pain from the common cold or flu
- Fast-acting relief: Tylenol Extra Strength Rapid Release Gels feature 500 mg acetaminophen per gelcap to temporarily relieve minor aches and pains from headache, backache, arthritis, toothache, menstrual cramps, muscle aches, and fever; 100-count
- Dosage instructions: Adults and children 12 years and older take two gelcaps every six hours while symptoms last; do not exceed six gelcaps in 24 hours; always follow the label directions for safe use of acetaminophen and dosing guidance
- Doctor-recommended brand: Choose Tylenol, the #1 doctor-recommended brand for pain relief and fever reduction based on 2021 IQVIA survey; over-the-counter medication with 500 mg acetaminophen per gelcap that’s gentle on the stomach
$11.85
$16.59 (29% Off)
5
Best Value
43% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Imodium
43% Off

Imodium A-D Fast-Acting Anti-Diarrheal Softgels, Loperamide HCl 2 mg, Travel Essential Diarrhea Relief Medicine for Adults, 24 Count, Anti Diarrhea Pills, Ages 12+, Easy to Swallow

Imodium

$12.38

$21.81
(43% Off)

More Details
Main highlights
- Travel essential: convenient tear-away blister packs provide compact, portable softgel packs for road trip essentials and everyday carry; trusted diarrhea medication for adults and older kids 12+ fits easily in purse, backpack or carry-on bag
- Restores natural balance: nonstimulant formula works with your body to restore digestive rhythm by gently slowing gut activity; supports nutrient absorption and minimizes cramps and urgency for comfortable, reliable relief
- Fast-acting relief: softgels with loperamide HCl 2 mg work in as little as one hour to control diarrhea symptoms; clinically proven anti-diarrheal formula slows intestinal movement faster than bismuth subsalicylate for rapid, reliable symptom control
- Doctor-recommended brand: Imodium A-D offers trusted symptom control for acute and Traveler’s diarrhea; these anti diarrhea pills are formulated with loperamide HCl 2 mg for gentle yet effective relief
- Clear dosing instructions: each softgel contains 2 mg loperamide hydrochloride; take two after the first loose stool and one after each subsequent stool, up to four in 24 hours; HSA/FSA eligible anti-diarrheal medicine
$12.38
$21.81 (43% Off)

Best over counter medications - January 2026

Advil Liqui-Gels minis Pain Reliever and Fever Reducer, Pain Medicine for Adults with Ibuprofen 200mg for Pain Relief - 200 Liquid Filled Capsules

Advil Liqui-Gels minis Pain Reliever and Fever Reducer, Pain Medicine for Adults with Ibuprofen 200mg for Pain Relief - 200 Liquid Filled Capsules

Tylenol Extra Strength Acetaminophen Rapid Release Gels, Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes for Fast Release, Gentle on Stomach, 500 mg Per Gelcap, 100 Count OTC Medicine

Tylenol Extra Strength Acetaminophen Rapid Release Gels, Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes for Fast Release, Gentle on Stomach, 500 mg Per Gelcap, 100 Count OTC Medicine

Imodium A-D Fast-Acting Anti-Diarrheal Softgels, Loperamide HCl 2 mg, Travel Essential Diarrhea Relief Medicine for Adults, 24 Count, Anti Diarrhea Pills, Ages 12+, Easy to Swallow

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Imodium A-D Fast-Acting Anti-Diarrheal Softgels, Loperamide HCl 2 mg, Travel Essential Diarrhea Relief Medicine for Adults, 24 Count, Anti Diarrhea Pills, Ages 12+, Easy to Swallow

VICKS DayQuil & NyQuil SEVERE Co-Pack, Cold & Flu Medicine, Powerful Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Congestion, Sinus Pressure, Stuffy Nose, and Cough, 48 LiquiCaps

VICKS DayQuil & NyQuil SEVERE Co-Pack, Cold & Flu Medicine, Powerful Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Congestion, Sinus Pressure, Stuffy Nose, and Cough, 48 LiquiCaps

Benadryl Ultratabs Allergy Medicine, 25 mg Diphenhydramine HCl Antihistamine Tablets For Cold & Allergy Relief of Symptoms Like Sneezing, Runny Nose, Itchy Eyes & Throat, Hay Fever, 100 Count Tablets

Benadryl Ultratabs Allergy Medicine, 25 mg Diphenhydramine HCl Antihistamine Tablets For Cold & Allergy Relief of Symptoms Like Sneezing, Runny Nose, Itchy Eyes & Throat, Hay Fever, 100 Count Tablets

Ricola MAX Throat Care Honey Lemon Drops with Extra Menthol Liquid Center - Maximum Cough and Sore Throat Relief for Cold & Flu Symptoms - 34 Count - Herbal Lozenges

Ricola MAX Throat Care Honey Lemon Drops with Extra Menthol Liquid Center - Maximum Cough and Sore Throat Relief for Cold & Flu Symptoms - 34 Count - Herbal Lozenges

Amazon Basic Care Loperamide Hydrochloride Tablets, 2 mg, Anti-Diarrheal, 24 Count (Pack of 1) (Packaging may vary)

Amazon Basic Care Loperamide Hydrochloride Tablets, 2 mg, Anti-Diarrheal, 24 Count (Pack of 1) (Packaging may vary)

TUMS Chewy Bites Chewable Antacid Tablets with Gas Relief, Lemon & Strawberry - 54 Count

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