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Best cold flu medicines - July 2026

Last Updated - July 22, 2026

1
Best Choice
22% Off

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Sambucol
22% Off

Sambucol Cold and Flu Relief Tablets - Homeopathic Black Elderberry Cold Medicine, Drowsy Free Remedy for Adults with Zinc, Quick-Dissolving Tablets for Men and Women - 60 Count

Sambucol

(22% Off)

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Main highlights
- THE ORIGINAL AND #1 ELDERBERRY BRAND - Sambucol is scientifically studied and has decades of experience making high-quality black elderberry supplements you can trust
- NATURAL SYNERGY - Formulated to complement other Sambucol products, including our syrups, gummies and throat lozenges
- FAMILY-FRIENDLY RELIEF - These tablets are ideal for the whole family, providing effective cold and flu relief with the strength you need, without causing drowsiness
- DISSOLVING TABLETS - Quick-dissolving tablets melt in your mouth without the need for water, helping you feel better fast
- COLD & FLU RELIEF - For temporary relief from cold & flu symptoms: congestion, runny nose, sore throat, cough, sinus discomfort, and fever
(22% Off)
2

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Amazon Basic Care

Amazon Basic Care Cold and Flu Relief, Daytime and Nighttime Combo Pack Softgels for Multi-Symptom Relief, Sore Throat, Cough, Nasal Congestion, Headache, 48 Count (Pack of 1)

Amazon Basic Care

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Main highlights
- PAIN RELIEVER AND FEVER REDUCER: Both Daytime and Nighttime cold medicine contain acetaminophen to help relieve aches, fever and sore throat
- NON-DROWSY DAYTIME COLD AND FLU MEDICINE provides multi-symptom relief of headache, fever, sore throat, nasal congestion, cough, and minor aches and pains
- NIGHTTIME COLD AND FLU MEDICINE provides multi-symptom relief of headache, fever, sore throat, sneezing, runny nose, cough, and minor aches and pains
- COLD AND FLU: Influenza (flu) and the common cold are respiratory illnesses caused by viruses. A cold medicine like Cold & Flu Relief Multi-Symptom Daytime/Nighttime can help
- ACTIVE INGREDIENTS: Compare to the active ingredients in Vicks DayQuil Cold & Flu and Vicks NyQuil Cold & Flu
3

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Amazon Basic Care

Amazon Basic Care Vapor Ice Day and Night Severe Cold and Flu Relief Caplets, Maximum Strength Multi-Symptom Medicine for Cough, Sore Throat, Nasal Congestion, 48 Count

Amazon Basic Care

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Main highlights
- MAXIMUM STRENGTH: Get day and night cold and flu relief with these max strength coated caplets. Relieve sore throat and other cold and flu symptoms with Amazon Basic Care Vapor Ice Daytime and Nighttime Severe Cold and Flu
- EFFECTIVE: Daytime relieves minor aches and pains, fever, nasal congestion, sinus pressure, cough and chest congestion; Nighttime relieves minor aches and pains, fever, nasal congestion, sinus pressure, sneezing, runny nose and cough
- COMBINATION PACK: Amazon Basic Care Vapor Ice Daytime and Nighttime Severe Cold and Flu comes in a combination pack for around-the-clock maximum strength, multi-symptom relief for your worst cold and flu symptoms
- COATED CAPLETS: Contain pain reliever/fever reducer, cough suppressant, nasal decongestant, antihistamine, expectorant (antihistamine in nighttime only, expectorant in daytime only)
- ACTIVE INGREDIENTS: Amazon Basic Care Vapor Ice Daytime and Nighttime Severe Cold and Flu help to relieve common cold and flu symptoms, day and night; compare to the active ingredients in Vicks DayQuil and NyQuil Severe VapoCOOL
4

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Tylenol

Tylenol Cold + Flu Severe Daytime + Nighttime Cold Medicine Caplets Combo Pack for Multi-Symptom, Cough, Sore Throat, Headache, Nasal Congestion Relief, Acetaminophen, Pain Reliever, 24 Count

Tylenol

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Main highlights
- The Nighttime relief caplets help reduce fever and relieve runny nose, sneezing, headache, cough, sore throat, nasal congestion, sinus congestion, and pressure
- The Daytime relief caplets are formulated to reduce fever, loosen phlegm and relieve headache, body aches, cough, sore throat, nasal congestion and chest congestion
- The Daytime caplets also contain guaifenesin 200 mg, an expectorant to help loosen phlegm (mucus) to make coughs more productive. The Nighttime caplets also contain 2 mg of chlorpheniramine maleate, an antihistamine
- Each cold & flu caplet contains 325 mg of acetaminophen, a pain reliever and fever reducer; 5 mg of phenylephrine HCl, a nasal decongestant; and 10 mg of dextromethorphan HBr, a cough suppressant
- 24-count combo pack of Tylenol Cold + Flu Severe Day/Night Caplets for multi-symptom cold and flu symptom relief. Combo pack includes 16 Daytime and 8 Nighttime caplets for relief when you need it
5
Best Value
24% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Mucinex
24% Off

Mucinex Fast-Max Cold and Flu & Nightshift Medicine for Adults, Over-the-Counter Medication Combo Pack for Sore Throat Relief, Decongestant, Cough & Cold Medicine (2 x 6 Fl Oz)

Mucinex

(24% Off)

More Details
Main highlights
- USAGE: Use as directed; For ages 12+ years
- SORE THROAT RELIEF: Both liquids contain Acetaminophen, which helps reduce fever and relieves sore throat, headache, and body pain
- NIGHTTIME COLD AND FLU MEDICINE FOR ADULTS: Nighttime liquid contains Triprolidine HCl, an antihistamine, which helps relieve runny nose & sneezing
- NASAL DECONGESTANT: Both liquids contain Phenylephrine HCl, a nasal decongestant, which helps relieve stuffy nose, sinus pressure, & nasal congestion
- COUGH MEDICINE FOR ADULTS: Both liquids contain Dextromethorphan HBr, which helps suppress and quiet cough
- COUGH COLD AND FLU MEDICINES FOR ADULTS: This combo pack of Maximum Strength Mucinex Fast-Max Cold & Flu and Nightshift Severe Cold & Flu provides powerful multi-symptom cold and flu relief for your worst cold and flu symptoms
- CHEST CONGESTION RELIEF: Daytime liquid contains Guaifenesin, an expectorant, which helps relieve chest congestion and thins and loosens mucus
(24% Off)

Best cold flu medicines - July 2026

Sambucol Cold and Flu Relief Tablets - Homeopathic Black Elderberry Cold Medicine, Drowsy Free Remedy for Adults with Zinc, Quick-Dissolving Tablets for Men and Women - 60 Count

Amazon Basic Care Cold and Flu Relief, Daytime and Nighttime Combo Pack Softgels for Multi-Symptom Relief, Sore Throat, Cough, Nasal Congestion, Headache, 48 Count (Pack of 1)

Amazon Basic Care Vapor Ice Day and Night Severe Cold and Flu Relief Caplets, Maximum Strength Multi-Symptom Medicine for Cough, Sore Throat, Nasal Congestion, 48 Count

Tylenol Cold + Flu Severe Daytime + Nighttime Cold Medicine Caplets Combo Pack for Multi-Symptom, Cough, Sore Throat, Headache, Nasal Congestion Relief, Acetaminophen, Pain Reliever, 24 Count

Mucinex Fast-Max Cold and Flu & Nightshift Medicine for Adults, Over-the-Counter Medication Combo Pack for Sore Throat Relief, Decongestant, Cough & Cold Medicine (2 x 6 Fl Oz)

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Tylenol Cold + Flu Severe Medicine Caplets for Cold & Flu Symptom Relief, Fever Reducer, Pain Reliever, Cough Suppressant, Nasal Decongestant & Expectorant with Acetaminophen, 24 ct.

Mucinex Fast-Max Maximum Strength Day & Night Cold and Flu Medicine for Adults, Powerful Over-the-Counter Medication for Cold & Flu Symptoms, Fast Dissolving Liquid Gels, 24 Count

Vicks DayQuil & NyQuil Co-Pack, Cold & Flu Medicine, Powerful Multi-Symptom Daytime & Nighttime Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, & Cough, 72ct

Amazon Basic Care Daytime Cold & Flu Liquid Caps; Cold Care for Daytime Cold and Flu, Orange, 48 Count (Pack of 1)

Coricidin HBP Maximum Strength Cold & Flu Day & Night Sugar-Free Liquid Twinpack, Decongestant-Free Cold Medicine for Adults with High Blood Pressure -12 Fl Oz (Pack of 2)

Vicks, DayQuil and NyQuil Severe Co-Pack, Cold and Flu Medicine, Powerful Relief for Headache, Fever, Sore Throat, Minor Aches and Pains, Congestion, Sinus Pressure, Stuffy Nose, 48 LiquiCaps

Boiron Oscillococcinum for Relief from Flu-Like Symptoms of Body Aches, Headache, Fever, Chills, and Fatigue - 30 Doses

Amazon Basic Care Night Time Cold & Flu Liquid, Cherry, 12 Fl Oz (Pack of 1)

Amazon Basic Care Daytime Severe Cold & Flu Relief Caplets, Multi-Symptom Relief for Headache, Fever, Sore Throat, Chest & Nasal Congestion, Vapor Ice, 24 Count

Amazon Basic Care Maximum Strength Daytime Honey Flavor Severe Cold and Flu Relief, Multi-Symptom, Non-Drowsy, Cough, Sore Throat, Nasal Congestion, Liquid Medicine, 12 fl oz (Pack of 1)

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