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Best sinus medicines - April 2026

Last Updated - April 26, 2026

1
Best Choice

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Mucinex

Mucinex Rapid Clear Maximum Strength Cold Medicine & Expectorant, Fever, Pain, Headache, & Excess Mucus Relief with Acetaminophen & Guaifenesin, Rapid Release Caplets for Adults, 20 Count

Mucinex

$13.97

More Details
Main highlights
- RAPID RELEASE CAPLETS: Mucinex Rapid Clear caplets start working fast
- PAIN RELIEF: Acetaminophen helps reduce fever and helps relieve body aches and headache associated with cold and flu
- MAXIMUM STRENGTH & NON-DROWSY: With Mucinex Rapid Clear, it's not "power through with a pounding headache" season—It's comeback season
- HEADACHE RELIEF: Helps relieve headaches including those associated with cold and flu
- EXPECTORANT: Contains Guaifenesin, an expectorant that aids in thinning and loosening mucus for more productive coughs and chest congestion relief
- EXCESS MUCUS RELIEF: The expectorant, Guaifenesin, provides effective excess mucus relief by thinning and loosening bothersome mucus in your chest, helping to clear chest congestion
- COLD MEDICINE: Mucinex Rapid Clear Pain, Headache, & Mucus Congestion is a trusted cold medicine for adults, offering comprehensive relief from cold and flu symptoms including fever, body pain, sore throat, headache, and excess mucus
$13.97
2

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Mucinex

Mucinex Rapid Clear Maximum Strength Cold Medicine & Expectorant, Fever, Pain, Headache, & Excess Mucus Relief with Acetaminophen & Guaifenesin, Rapid Release Caplets for Adults, 20 Count

Mucinex

$13.27

$13.97
(5% Off)

More Details
Main highlights
- RAPID RELEASE CAPLETS: Mucinex Rapid Clear caplets start working fast
- PAIN RELIEF: Acetaminophen helps reduce fever and helps relieve body aches and headache associated with cold and flu
- MAXIMUM STRENGTH & NON-DROWSY: With Mucinex Rapid Clear, it's not "power through with a pounding headache" season—It's comeback season
- HEADACHE RELIEF: Helps relieve headaches including those associated with cold and flu
- EXPECTORANT: Contains Guaifenesin, an expectorant that aids in thinning and loosening mucus for more productive coughs and chest congestion relief
- EXCESS MUCUS RELIEF: The expectorant, Guaifenesin, provides effective excess mucus relief by thinning and loosening bothersome mucus in your chest, helping to clear chest congestion
- COLD MEDICINE: Mucinex Rapid Clear Pain, Headache, & Mucus Congestion is a trusted cold medicine for adults, offering comprehensive relief from cold and flu symptoms including fever, body pain, sore throat, headache, and excess mucus
$13.27
$13.97 (5% Off)
3
15% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Sudafed
15% Off

Sudafed PE Sinus Pressure + Pain Relief Tablets, Maximum Strength, Non-Drowsy, OTC Sinus Relief Medicine with Acetaminophen Pain Reliever & Phenylephrine HCl Nasal Decongestant, 24 ct

Sudafed

$9.03

$10.67
(15% Off)

More Details
Main highlights
- PHENYLEPHRINE & ACETAMINOPHEN: Each sinus congestion and pressure relief tablet contains 5 mg of phenylephrine HCI, a nasal decongestant that provides non-drowsy relief, plus, 325 mg of acetaminophen, a pain and fever reducer
- NON-DROWSY COLD & SINUS MEDICINE: Sudafed sinus and pain medication helps to temporarily relieve nasal congestion associated with hay fever, upper respiratory allergies and the common cold, plus, helps relieve sinus pressure and sinus headaches
- HOW TO USE: Sudafed PE sinus pressure and pain relief congestion relief tablets can be used by adults and children ages 12 and up. Take two tablets every four hours; do not exceed 10 tablets within a 24 hour time period
- FSA HSA APPROVED PRODUCT: Sinus congestion relief and pain medicine from Sudafed, the #1 pharmacist recommended brand among oral OTC decongestants. Sudafed PE Sinus Pressure + Pain is HSA & FSA eligible. Product eligibility may vary by plan
- DECONGESTANT & PAIN RELIEF: 24-count package of Sudafed PE Sinus Pressure and Pain maximum strength non-drowsy decongestant tablets for fast and powerful relief of sinus congestion, sinus pressure, and nasal congestion
$9.03
$10.67 (15% Off)
4
Best Value
20% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Sudafed
20% Off

Sudafed PE Sinus Pressure + Pain Relief Tablets, Maximum Strength, Non-Drowsy, OTC Sinus Relief Medicine with Acetaminophen Pain Reliever & Phenylephrine HCl Nasal Decongestant, 24 ct

Sudafed

$8.58

$10.67
(20% Off)

More Details
Main highlights
- PHENYLEPHRINE & ACETAMINOPHEN: Each sinus congestion and pressure relief tablet contains 5 mg of phenylephrine HCI, a nasal decongestant that provides non-drowsy relief, plus, 325 mg of acetaminophen, a pain and fever reducer
- NON-DROWSY COLD & SINUS MEDICINE: Sudafed sinus and pain medication helps to temporarily relieve nasal congestion associated with hay fever, upper respiratory allergies and the common cold, plus, helps relieve sinus pressure and sinus headaches
- HOW TO USE: Sudafed PE sinus pressure and pain relief congestion relief tablets can be used by adults and children ages 12 and up. Take two tablets every four hours; do not exceed 10 tablets within a 24 hour time period
- FSA HSA APPROVED PRODUCT: Sinus congestion relief and pain medicine from Sudafed, the #1 pharmacist recommended brand among oral OTC decongestants. Sudafed PE Sinus Pressure + Pain is HSA & FSA eligible. Product eligibility may vary by plan
- DECONGESTANT & PAIN RELIEF: 24-count package of Sudafed PE Sinus Pressure and Pain maximum strength non-drowsy decongestant tablets for fast and powerful relief of sinus congestion, sinus pressure, and nasal congestion
$8.58
$10.67 (20% Off)
5
16% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Tylenol
16% Off

Tylenol Sinus + Headache Daytime Non-Drowsy Relief Caplets, Acetaminophen 325mg, Nasal Decongestant for Sinus Pressure, Headache & Nasal Congestion Relief, 24 ct

Tylenol

$8.99

$10.67
(16% Off)

More Details
Main highlights
- The non-drowsy formula of this sinus medicine provides effective daytime symptom relief by promoting sinus drainage and helping to decongest sinus openings and passages
- Pain reliever and nasal decongestant formulated to temporarily reduce fever and relieve symptoms of nasal congestion, sinus headache and pressure
- From the #1 doctor recommended pain relief brand, these daytime headache and sinus relief caplets are suitable for adults and children ages 12 years and older for powerful daytime cold symptom relief
- Each sinus relief caplet contains 325 milligrams of acetaminophen to temporarily relieve pain and reduce fever as well as 5 milligrams of phenylephrine HCl, a nasal decongestant to help clear nasal passages
- 24-count box of Tylenol Sinus + Headache Daytime Caplets for non-drowsy sinus symptom and headache pain relief due to the common cold, hay fever or other respiratory allergies
$8.99
$10.67 (16% Off)

Best sinus medicines - April 2026

Mucinex Rapid Clear Maximum Strength Cold Medicine & Expectorant, Fever, Pain, Headache, & Excess Mucus Relief with Acetaminophen & Guaifenesin, Rapid Release Caplets for Adults, 20 Count

Mucinex Rapid Clear Maximum Strength Cold Medicine & Expectorant, Fever, Pain, Headache, & Excess Mucus Relief with Acetaminophen & Guaifenesin, Rapid Release Caplets for Adults, 20 Count

Sudafed PE Sinus Pressure + Pain Relief Tablets, Maximum Strength, Non-Drowsy, OTC Sinus Relief Medicine with Acetaminophen Pain Reliever & Phenylephrine HCl Nasal Decongestant, 24 ct

Sudafed PE Sinus Pressure + Pain Relief Tablets, Maximum Strength, Non-Drowsy, OTC Sinus Relief Medicine with Acetaminophen Pain Reliever & Phenylephrine HCl Nasal Decongestant, 24 ct

Tylenol Sinus + Headache Daytime Non-Drowsy Relief Caplets, Acetaminophen 325mg, Nasal Decongestant for Sinus Pressure, Headache & Nasal Congestion Relief, 24 ct

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Tylenol Sinus + Headache Daytime Non-Drowsy Relief Caplets, Acetaminophen 325mg, Nasal Decongestant for Sinus Pressure, Headache & Nasal Congestion Relief, 24 ct

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Sudafed PE Sinus Congestion Relief Tablets, Maximum Strength, Non-Drowsy 10 mg Phenylephrine HCI Decongestant for Sinus Pressure & Nasal Congestion Relief, Due to Cold or Allergies, 36 ct

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Tylenol Sinus Severe Daytime Cold & Flu Relief Medicine Caplets, Non-Drowsy Pain Reliever, Fever Reducer Expectorant & Decongestant, Acetaminophen, Guaifenesin & Phenylephrine HCl, 24 ct

Tylenol Sinus Severe Daytime Cold & Flu Relief Medicine Caplets, Non-Drowsy Pain Reliever, Fever Reducer Expectorant & Decongestant, Acetaminophen, Guaifenesin & Phenylephrine HCl, 24 ct

Boiron SinusCalm Tablets for Sinus Pain Relief, Runny Nose, Congestion, Sinus Pressure, Headache - 60 Count

Boiron SinusCalm Tablets for Sinus Pain Relief, Runny Nose, Congestion, Sinus Pressure, Headache - 60 Count

Sinus Infection Treatment & Symptoms | Request prescription for sinus medication like nasal spray, antibiotics for sinus headache & pain symptom relief from an online doctor, NP, or PA

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